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pentobarbital will lessen the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will decrease the level or result of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Powerful CYP3A4 inducers are pr